Rejuran vs Profhilo: Which Skin Rejuvenation Treatment Is Better?

Rejuran and Profhilo are two popular injectable treatments designed to improve skin quality without dramatically changing your facial features. Both may help create smoother, fresher and healthier-looking skin, but they work in different ways.

Rejuran is a polynucleotide-based treatment that focuses on supporting skin repair and gradual regeneration. Profhilo is a hyaluronic acid injectable primarily used to improve hydration, elasticity and mild skin laxity.

So, which treatment is better?

There is no single winner for every patient. Profhilo may be more suitable when dehydration, dullness and early skin laxity are the main concerns. Rejuran may be more appropriate when the goal is to improve skin texture, fine lines, delicate under-eye skin or overall skin resilience.

The right choice depends on your skin condition, treatment area, expectations and medical history.

Rejuran vs Profhilo at a Glance

Feature	Rejuran	Profhilo
Main ingredient	Purified polynucleotides	Hybrid complexes of hyaluronic acid
Primary purpose	Skin repair and regeneration	Hydration and tissue remodelling
Best suited to	Fine lines, texture, delicate skin and gradual rejuvenation	Dehydration, crepey skin, reduced elasticity and mild laxity
Adds facial volume?	No significant structural volume	No significant structural volume
Common treatment areas	Face, under-eyes, neck, hands and selected scars	Face, neck, hands and areas of mild skin laxity
Results	Gradual improvement in skin quality	Hydration may appear earlier, with firmness developing gradually
Typical initial course	Often several sessions, depending on the product and concern	Commonly two sessions around one month apart
Downtime	Small bumps, redness, swelling or bruising	Temporary injection-point bumps, swelling or bruising
Overall advantage	More targeted regenerative approach	Strong focus on hydration and elasticity

These are general comparisons rather than fixed treatment rules. Injection methods, treatment schedules and expected results should always be personalised by a properly trained medical practitioner.

What Is Rejuran?

Rejuran is an injectable skin rejuvenation treatment formulated with purified polynucleotides, commonly referred to as PN. These long-chain molecules are obtained from highly purified salmon-derived DNA material.

Rather than filling wrinkles or reshaping the face, Rejuran is used to create an environment that supports healthier skin function. Polynucleotides can bind water and may influence processes associated with tissue repair, fibroblast activity and extracellular matrix development.

The Rejuran product range includes different formulations for different concerns. For example, Rejuran Healer is positioned for general facial rejuvenation, while Rejuran i is intended for thinner and more delicate skin. Other formulations may be selected for scars or improved treatment comfort.

Scientific reviews of injectable polynucleotides have reported promising improvements in areas such as skin texture, wrinkle appearance, hydration and elasticity. However, researchers also note that existing studies vary in quality, use different treatment protocols and frequently involve relatively small groups of patients. More high-quality comparative research is still needed.

What Skin Concerns Can Rejuran Address?

Depending on the formulation and treatment plan, Rejuran may be considered for:

• Fine lines and early signs of ageing
• Thin or crepey-looking skin
• Rough or uneven skin texture
• Reduced skin elasticity
• Tired-looking under-eye skin
• Enlarged-looking pores
• Mild acne scarring
• Skin affected by environmental or sun-related ageing

Rejuran is usually chosen by people who want gradual skin-quality improvement rather than an immediate filling or lifting effect.

What Is Profhilo?

Profhilo is an injectable treatment containing high- and low-molecular-weight hyaluronic acid in a hybrid cooperative complex.

Hyaluronic acid is naturally present in the body and plays an important role in skin hydration. Profhilo is designed to spread through the treated tissue rather than remain in one place like a traditional volumising dermal filler.

The standard Profhilo formulation contains 64 mg of hyaluronic acid in 2 ml. It is primarily used for skin bioremodelling and is intended to improve hydration, firmness, elasticity and mild skin laxity on areas such as the face and neck.

A clinical split-face study involving 24 women found that Profhilo and another hyaluronic acid skin revitaliser both produced improvements in several skin-quality measurements, particularly moisturisation. Side effects were generally described as mild and temporary.

What Skin Concerns Can Profhilo Address?

Profhilo is commonly considered for:

• Dry or dehydrated skin
• Dull-looking skin
• Crepey texture
• Reduced firmness
• Early skin laxity
• Fine lines associated with dehydration
• Ageing skin on the face or neck
• Skin that needs an overall hydration boost

It is particularly attractive to patients who want their skin to appear fresher and more hydrated without changing the natural contours of their face.

What Is the Main Difference Between Rejuran and Profhilo?

The biggest difference is their primary ingredient and treatment focus.

Rejuran focuses on regenerative support

Rejuran contains polynucleotides. Its main purpose is to support gradual improvements in skin quality, resilience and texture.

It may be particularly useful for delicate, damaged or ageing skin where the objective is to encourage a healthier skin environment over time.

Profhilo focuses on hydration and bioremodelling

Profhilo contains stabilised hybrid complexes of hyaluronic acid. It is primarily selected to improve moisture levels, elasticity and mild skin laxity.

It may be better suited to people whose skin looks dry, dull, crepey or less firm but who do not require substantial facial volume.

Neither treatment should be viewed as a direct replacement for Botox, structural dermal fillers, laser resurfacing or surgical lifting. Each of those treatments addresses a different aspect of facial ageing.

Rejuran vs Profhilo for Skin Hydration

Profhilo will often be the more obvious choice when intense hydration is the main priority.

Its high concentration of hyaluronic acid is designed to distribute within the tissue and improve moisture, skin tone and elasticity. The manufacturer recommends an initial course of two sessions with approximately 30 days between treatments, although the final protocol should reflect the patient’s degree of ageing and individual needs.

Rejuran can also contribute to skin hydration because its long-chain polynucleotides bind water. However, hydration is usually considered part of its broader regenerative effect rather than its only purpose.

Potential winner for dehydration: Profhilo

Rejuran vs Profhilo for Fine Lines

Both treatments may soften the appearance of fine lines, but the best option depends on why those lines are visible.

Profhilo may help when fine lines are associated with dryness, reduced elasticity or crepey skin. By increasing hydration, the skin can appear smoother and more supple.

Rejuran may be selected when fine lines are accompanied by thin skin, rough texture or broader concerns about skin quality. Reviews of polynucleotide treatments have found encouraging results for wrinkle depth and elasticity, although the strength and consistency of the evidence remain limited.

Deep expression lines caused by repeated muscle movement may respond more effectively to botulinum toxin. Deeper folds caused by volume loss may require dermal filler or another structural treatment.

Potential winner for dry, crepey lines: Profhilo

Potential winner for thin skin and gradual texture improvement: Rejuran

Rejuran vs Profhilo for Skin Laxity

Profhilo is generally more closely associated with treating mild skin laxity.

It is designed for tissue remodelling and may improve firmness, elasticity and the appearance of mildly sagging skin. However, the result is usually subtle. Profhilo cannot provide the same degree of lifting as surgery and does not replace structural filler where significant volume loss is present.

Rejuran may improve the overall quality and elasticity of the skin, but it is not normally chosen as a primary lifting treatment.

Potential winner for mild laxity: Profhilo

Rejuran vs Profhilo for the Under-Eye Area

Rejuran is often considered the more targeted option for delicate under-eye skin.

Rejuran i is formulated for thin skin and may be used to improve fine lines, crepiness and general skin quality around the eyes.

However, under-eye concerns can have several causes. Dark circles may result from pigmentation, visible blood vessels, hollow tear troughs, shadowing, allergies or lifestyle factors. Polynucleotide injections will not correct every type of dark circle.

Standard Profhilo is not usually injected in the same superficial pattern across the tear trough. A practitioner may recommend a different Profhilo technique or another product depending on the anatomy and concern.

Because the eye area has complex blood vessels and delicate tissue, it should only be treated by a practitioner with appropriate anatomical training and injectable experience.

Potential winner for thin, crepey under-eye skin: Rejuran

Rejuran vs Profhilo for Acne Scars

Rejuran may be considered as part of a treatment plan for selected acne scars, particularly when the goal is to improve surrounding skin quality.

The Rejuran range includes a formulation positioned for general scars and depressed areas. Research has also explored polynucleotide-based therapies for facial scars, although acne-scar treatment usually requires a personalised combination approach.

Profhilo is not normally the first treatment chosen for established indented acne scars. Treatments such as subcision, microneedling, fractional laser, chemical reconstruction techniques or selected fillers may be more suitable depending on the scar type.

Neither Rejuran nor Profhilo should be presented as a universal acne-scar cure.

Potential winner for supporting scar-related skin quality: Rejuran

Which Treatment Produces Faster Results?

Profhilo may produce a more noticeable early improvement in hydration and skin freshness. However, its remodelling effects continue to develop gradually following the treatment course.

Rejuran results are generally expected to be progressive. Patients may notice improvements in smoothness, texture or elasticity over several weeks as the skin responds to treatment.

The speed of improvement varies according to:

• Age
• Baseline skin condition
• Treatment area
• Product formulation
• Number of sessions
• Injection technique
• Sun exposure
• Smoking
• Skincare habits
• General health

Neither treatment should be expected to produce the immediate structural change associated with a volumising dermal filler.

How Many Sessions Are Needed?

Profhilo treatment schedule

A commonly recommended starting protocol for standard Profhilo is two treatment sessions approximately 30 days apart. Maintenance sessions can then be considered according to the patient’s response and degree of skin ageing.

Rejuran treatment schedule

Rejuran protocols are less uniform because several formulations exist and practitioners may use different techniques. A course often involves multiple appointments spaced several weeks apart, followed by maintenance where appropriate.

Your practitioner should explain why a particular number of sessions is being recommended rather than applying the same package to every patient.

Which Treatment Is More Painful?

Rejuran usually involves numerous small intradermal injections across the treatment area. This can create a stinging or burning sensation, and the number of injection points may make the session feel more intensive.

Depending on the formulation, topical anaesthetic or an integrated local anaesthetic may be used to make the procedure more comfortable.

Standard facial Profhilo is commonly administered using the Bio Aesthetic Points technique. This generally involves five injection points on each side of the face, allowing the product to distribute through the tissue.

Pain tolerance differs between patients, and comfort also depends on the treatment area, needle technique and practitioner experience.

Potential winner for fewer facial injection points: Profhilo

Rejuran vs Profhilo Downtime

Both are minimally invasive injectable procedures, but temporary side effects are possible.

Possible Rejuran side effects

Patients may experience:

• Small raised bumps
• Redness
• Swelling
• Tenderness
• Bruising
• Temporary itching or sensitivity

Clinical reviews report that the most common side effects from injectable polynucleotides are mild redness and swelling that typically resolve within a few days.

Because Rejuran is often injected through many small points, the visible bumps may be more widespread immediately after treatment.

Possible Profhilo side effects

Patients may experience:

• Small bumps at injection points
• Mild swelling
• Redness
• Tenderness
• Bruising
• Temporary discomfort

A safety assessment of high- and low-molecular-weight hyaluronic acid complexes found that early injection-site reactions, including swelling, redness, bruising and erythema, were the most frequently observed effects.

Although serious complications are uncommon, any injectable procedure can carry additional risks, including infection and vascular injury. The qualifications of the practitioner, knowledge of facial anatomy, hygiene standards and ability to manage complications are therefore extremely important.

Seek urgent medical assistance if you experience severe or increasing pain, unusual skin discolouration, visual symptoms, spreading redness, breathing difficulty or signs of a serious allergic reaction after an injectable procedure.

Which Treatment Looks More Natural?

Both treatments are designed to improve skin quality rather than dramatically alter facial shape.

Profhilo does not usually create the projection or contouring effect associated with traditional dermal fillers. It aims to make the skin appear more hydrated, elastic and refreshed.

Rejuran also produces gradual changes. The objective is generally healthier-looking, smoother and more resilient skin rather than an obviously “filled” appearance.

For patients worried about looking overdone, either treatment may be appropriate when used conservatively and selected for the right concern.

Who May Be Better Suited to Rejuran?

Rejuran may be worth discussing when you:

• Have thin or crepey skin
• Want to improve fine lines and skin texture
• Are concerned about delicate under-eye skin
• Prefer gradual regenerative treatment
• Have rough or environmentally damaged-looking skin
• Want to support the quality of skin around selected scars
• Do not need significant volume or facial contouring

Who May Be Better Suited to Profhilo?

Profhilo may be worth discussing when you:

• Have dehydrated or dull skin
• Want a stronger hydration-focused treatment
• Have mild skin laxity
• Notice crepey skin on the face or neck
• Want better firmness and elasticity
• Prefer fewer standard facial injection points
• Want subtle rejuvenation without adding structural volume

Can Rejuran and Profhilo Be Combined?

Some practitioners may use Rejuran and Profhilo within the same overall rejuvenation plan because they have different treatment priorities.

For example, Profhilo may be used to target general dehydration and elasticity, while Rejuran may be selected for texture or delicate areas. They may also be combined with treatments such as botulinum toxin, dermal fillers, microneedling or energy-based procedures.

However, more treatment does not automatically mean better results. Combining procedures can increase cost, swelling, bruising and recovery requirements.

A staged treatment plan is often preferable because it allows the practitioner to assess how your skin responds before introducing another procedure.

Rejuran vs Profhilo: Which One Is Better?

The better treatment depends on what you want to improve.

Choose Profhilo when your main concerns are:

• Dehydration
• Dullness
• Crepey skin
• Reduced elasticity
• Mild skin laxity
• General loss of skin freshness

Choose Rejuran when your main concerns are:

• Fine lines
• Thin or delicate skin
• Under-eye skin quality
• Uneven texture
• Enlarged-looking pores
• Gradual skin regeneration
• Supporting the appearance of selected scars

Current clinical literature supports possible skin-quality benefits from both hyaluronic acid hybrid complexes and injectable polynucleotides. However, there is not yet strong, large-scale head-to-head evidence proving that one is universally superior to the other. Polynucleotide reviews also emphasise the need for more standardised and higher-quality studies.

The most important decision is therefore not simply Rejuran or Profhilo. It is choosing the treatment that matches your concern and having it performed by a qualified practitioner using an authentic product and an appropriate injection technique.

Frequently Asked Questions

Is Rejuran better than Profhilo?

Rejuran is not automatically better than Profhilo. Rejuran may be more suitable for texture, thin skin, fine lines and under-eye rejuvenation. Profhilo may be more suitable for dehydration, reduced elasticity and mild skin laxity.

Is Profhilo better for glowing skin?

Profhilo is commonly chosen for dull or dehydrated skin because its hyaluronic acid formulation focuses strongly on hydration. Better hydration may make the complexion appear smoother, fresher and more radiant.

Does Rejuran add volume to the face?

Rejuran is not intended to provide the same structural volume or facial contouring as a traditional dermal filler. Any early fullness is more likely to be related to temporary swelling from the injections.

Does Profhilo change the shape of your face?

Standard Profhilo is not designed to reshape facial features. It spreads through the treated tissue to improve hydration and skin quality rather than creating targeted projection.

Can Rejuran help dark circles?

Rejuran may improve the quality of thin, crepey under-eye skin, but it will not correct every cause of dark circles. Pigmentation, vascular visibility, hollowness, allergies and shadowing may require different treatments.

Is Rejuran made from salmon sperm?

Rejuran contains highly purified polynucleotides derived from salmon DNA material. The final injectable product undergoes purification and manufacturing processes; it should not be understood as untreated biological material.

How long do Rejuran and Profhilo results last?

Results vary considerably. Skin condition, treatment course, lifestyle, metabolism and maintenance schedule all influence how long improvements remain visible. Your practitioner should avoid guaranteeing an exact duration before assessing your skin.

Can Profhilo or Rejuran replace dermal fillers?

Neither treatment is a direct substitute for structural dermal fillers. Rejuran and standard Profhilo mainly improve skin quality. Dermal fillers are used when the objective is to restore volume, support facial structure or change contour.

Is there any downtime after treatment?

Most patients can return to normal activities relatively quickly, but visible bumps, swelling, redness or bruising may remain for several hours or days. Avoid scheduling treatment immediately before an important event.

Final Thoughts

Rejuran and Profhilo both offer subtle, non-surgical skin rejuvenation, but they solve different problems.

Profhilo is usually the stronger choice for deep hydration, crepey skin and early loss of elasticity. Rejuran is often better suited to fine lines, delicate under-eye skin, uneven texture and gradual regenerative improvement.

A consultation should include an assessment of your skin, medical history, previous treatments, expectations and suitability for injectable procedures. Your practitioner should also discuss alternative options, realistic outcomes, possible complications and the exact product being used.

Medical disclaimer: This article is for general educational purposes and does not replace personalised medical advice. Injectable treatments should only be performed following an appropriate consultation with a suitably qualified and experienced healthcare professional.