Acne scars can affect both skin texture and confidence. Depending on the type of scarring, the skin may develop shallow depressions, deeper pits, uneven contours or persistent textural irregularities. Although several treatments are available, not every option works in the same way or is suitable for every type of scar.
Rejuran is an injectable skin treatment containing polynucleotides (PN), commonly described as DNA-derived molecules used in skin-rejuvenation treatments. It is intended to support skin quality and repair-related processes. For people concerned about acne scars, the key question is whether Rejuran can meaningfully improve uneven texture and how it compares with treatments designed specifically for depressed scars.
This guide explains how Rejuran may help acne-scar concerns, what results to expect, which scar types may need other treatments, and how a personalised treatment plan can be developed with an aesthetic doctor.
What Is Rejuran?
Rejuran is an injectable treatment formulated with polynucleotides (PN). It is used in aesthetic medicine to support skin quality, hydration and the appearance of skin texture.
Rather than acting as a conventional dermal filler that primarily adds volume, Rejuran is generally positioned as a skin-quality treatment. Its intended effects and the degree of improvement can vary according to the product used, treatment technique, individual skin condition and the concern being addressed.
When considering Rejuran for acne scars, it is important to distinguish between improving the overall appearance of the skin and correcting the structural depressions associated with established atrophic scars. These are different treatment goals and may require different approaches.
Learn more about the treatment on our Rejuran treatment page.
Can Rejuran Improve Acne Scars?
Rejuran may be considered as part of a treatment plan for certain acne-scar concerns, particularly when uneven skin texture and overall skin quality are also priorities. However, it should not be presented as a guaranteed solution for every type of acne scar.
Acne scars vary in depth, shape and underlying structure. Some scars are relatively shallow, while others are tethered to deeper tissue or form narrow, deep pits. The treatment most likely to help depends on these characteristics.
1. Supporting Overall Skin Texture
Rejuran is used to support skin quality and may be considered when the skin looks uneven, rough or less smooth. Any improvement in texture varies between individuals, and evidence for general skin rejuvenation should not automatically be interpreted as proof that deep acne scars can be corrected.
2. Supporting Skin Repair-Related Processes
Polynucleotides are studied for their potential role in tissue-repair-related processes. This is one reason they have attracted interest in aesthetic treatments. However, the proposed biological mechanisms do not guarantee a particular clinical outcome, and evidence specifically involving acne scars remains an important consideration.
3. Complementing a Broader Acne-Scar Plan
For some patients, skin quality is only one part of the concern. Depressed scars may also involve collagen loss, fibrous tethering or sharply defined scar edges. Rejuran alone may not adequately address these structural features. A doctor may therefore discuss other procedures, either instead of or alongside skin-quality treatments, depending on suitability.
What Does the Evidence Say About Rejuran for Acne Scars?
Research into polynucleotide-based treatments has explored their potential role in skin rejuvenation and tissue repair. However, the amount and quality of evidence can vary according to the product formulation, study design and condition being treated.
Small clinical studies and research involving combination formulations may provide useful early findings, but they should be interpreted carefully. Results from a study of a specific PN or PN-plus-hyaluronic-acid formulation cannot automatically be applied to every Rejuran product, injection technique or acne-scar type.
When reviewing treatment claims, consider the following:
- Study size: Small studies may not reflect the range of outcomes seen in a larger patient population.
- Product formulation: Findings from one formulation may not apply to another.
- Type of acne scar: Improvements in general skin quality are not necessarily equivalent to improvement in deep or tethered scars.
- Outcome measurements: Changes in skin texture, patient satisfaction and measured scar depth are different outcomes.
- Combination treatments: If several procedures are used together, it may be difficult to determine how much improvement came from Rejuran alone.
A consultation should therefore focus on realistic, measurable goals rather than promising complete scar removal.
Which Types of Acne Scars May Need Different Treatments?
Understanding the type of scar is essential when choosing an appropriate treatment. Rejuran may be discussed as part of an overall skin-quality plan, but established depressed scars often require a treatment selected specifically for their structure.
Ice Pick Scars
Ice pick scars are narrow, deep depressions that extend into the skin. Because of their depth and small surface opening, they may respond poorly to treatments that focus mainly on general skin quality. A doctor may consider scar-specific approaches such as TCA CROSS or selected procedural options after assessing the scar.
Boxcar Scars
Boxcar scars have more defined edges and a wider, depressed appearance. Depending on their depth and characteristics, treatment options may include fractional resurfacing, microneedling-based procedures or other scar-directed techniques. Deeper scars may require a different approach from shallow ones.
Rolling Scars
Rolling scars create a wave-like or uneven surface, sometimes because fibrous bands pull the skin downward. Where tethering is present, subcision may be considered to release these bands. Skin-quality treatments alone may not address the underlying tethering.
Uneven Texture and Mild Surface Irregularities
People whose main concern is mild unevenness, rough texture or overall skin quality may discuss Rejuran as one possible option. The expected benefit should be assessed separately from the correction of deeper, established scars.
Raised Acne Scars
Raised scars, including hypertrophic scars and keloids, are different from depressed acne scars. They require assessment and treatment approaches appropriate to raised scar tissue. Rejuran should not be assumed to be a suitable treatment for these concerns.
Rejuran vs Other Acne-Scar Treatments
There is no single treatment that is best for every acne scar. The following options work differently, and a clinician may recommend one approach or a combination based on scar type, skin condition, medical history and tolerance for downtime.
Rejuran
Rejuran is primarily considered a skin-quality treatment. It may be discussed when improving overall texture is part of the goal, but it should not be relied upon as the sole solution for deep pits or scars tethered to underlying tissue.
Microneedling
Microneedling creates controlled micro-injuries in the skin to stimulate a healing response. It may be considered for certain forms of mild to moderate atrophic scarring, depending on the device, treatment protocol and individual skin characteristics.
RF Microneedling
Radiofrequency microneedling combines microneedles with radiofrequency energy. It may be used for selected concerns involving acne scars and skin texture. Suitability, risks and expected outcomes depend on the device and the individual patient.
Fractional Laser Resurfacing
Fractional laser treatments create controlled treatment zones in the skin and may help improve selected textural irregularities. The type of laser, treatment intensity, skin type and risk of post-inflammatory hyperpigmentation should be assessed before treatment.
Subcision
Subcision is a scar-directed procedure that releases fibrous bands beneath selected depressed scars. It may be particularly relevant when rolling scars are tethered to deeper tissue. It does not replace every other treatment and may be combined with additional procedures when appropriate.
TCA CROSS and Other Scar-Directed Procedures
TCA CROSS uses a high-concentration chemical application on selected individual scars and may be considered for certain narrow, deep scars. Other options, including punch techniques or carefully selected fillers, may be discussed for particular scar patterns.
The right choice depends on the actual scar structure rather than the treatment’s popularity. A detailed assessment can help establish which concern should be treated first.
Can Rejuran Improve Enlarged Pores and Uneven Skin Texture?
Acne scars are not the only reason someone may seek smoother-looking skin. Enlarged pores, rough texture and uneven skin appearance can occur alongside acne scarring, but they are not identical concerns.
Rejuran may be discussed when overall skin quality is a treatment priority. However, pore size and visible texture are influenced by several factors, including genetics, oil production, skin elasticity and previous inflammation. Improvement is not guaranteed, and a treatment that helps general skin quality may not correct a deep scar.
If enlarged pores are your main concern, read our guide to Rejuran for enlarged pores.
Should Rejuran Be Used Alone or Combined With Other Treatments?
The answer depends on the type of acne scars and the overall condition of the skin. Some patients may benefit from focusing on one treatment first, while others may need a staged plan that addresses different aspects of scarring.
For example, a treatment intended to release tethered scars addresses a different problem from one intended to improve general skin quality. Combining procedures does not automatically produce better results, and the timing of each treatment should be decided by a qualified clinician.
Before agreeing to a combination plan, ask your doctor:
- Which specific scar types are being targeted?
- What is the purpose of each treatment?
- Could one treatment affect the safety or recovery of another?
- How much downtime should be expected from the complete plan?
- How will improvement be measured?
What Happens During a Rejuran Treatment?
The exact process depends on the product used and the clinic’s protocol. A typical appointment may include the following steps:
- Consultation and assessment: The clinician reviews your skin, acne-scar pattern, medical history and treatment goals.
- Skin preparation: The treatment area is cleansed. A topical numbing product may be used when appropriate.
- Injection: The product is administered using a technique selected by the treating clinician.
- Aftercare guidance: You receive instructions on caring for your skin and managing common short-term reactions.
Appointment duration varies according to the area treated, the product and the clinic’s protocol. Ask the clinic how much time to allow for consultation, preparation and treatment.
Is Rejuran Painful?
Discomfort varies between individuals and depends on the injection technique, treatment area and use of numbing measures. Patients may experience stinging or brief discomfort during injections. If you are concerned about pain, discuss pain-management options with your clinician before treatment.
What Is the Downtime After Rejuran?
After injectable Rejuran treatment, temporary injection-site bumps, redness, swelling, tenderness or bruising may occur. The duration and severity vary between individuals and may depend on the treatment area and injection technique.
Some visible reactions may settle within a few days, while bruising or other local effects can take longer to resolve. Do not assume that everyone will recover on the same schedule.
Follow the aftercare instructions provided by your treating clinic. Avoid rubbing or applying pressure to treated areas unless your clinician advises otherwise, and ask when it is appropriate to resume exercise, makeup and active skincare products.
For more detailed recovery guidance, see our article on Rejuran downtime and aftercare.
How Many Rejuran Sessions Are Needed for Acne Scars?
The number of sessions depends on the treatment goal, the product used, the condition of the skin and the clinician’s assessment. There is no universal session count that guarantees improvement in acne scars.
It is also important to distinguish between a treatment plan intended to improve general skin quality and one designed to correct deeper structural scarring. A series of Rejuran sessions may not replace scar-specific procedures when those are needed.
Ask your clinician what degree of improvement is realistic, when progress should be reviewed and whether another treatment would be more appropriate for your particular scars.
Read more about how many Rejuran sessions may be recommended.
When Can You Expect to See Results?
Results vary according to the individual, the treatment protocol and the concern being addressed. Changes in skin quality may develop gradually, and visible improvement in general texture should not be confused with complete correction of established acne scars.
Before treatment, ask your clinician when results are usually reviewed, how progress will be assessed and what alternative options are available if the improvement is less than expected.
Are Rejuran Results Permanent?
Rejuran should not be presented as a permanent solution for acne scars. The longevity of any improvement depends on the concern being treated, the individual’s skin and the treatment plan. Existing scar structure may remain even when overall skin quality improves.
If your primary concern is deep or tethered scarring, discuss whether a scar-specific procedure is needed instead of relying on repeat skin-quality treatments alone.
Who May Be Suitable for Rejuran for Acne Scars?
Rejuran may be worth discussing with an aesthetic doctor if your goals include improving overall skin quality or addressing uneven texture as part of a broader treatment plan.
It may not be the most appropriate standalone option for every acne-scar pattern, especially where scars are deep, sharply defined or tethered to underlying tissue.
Your clinician should review your medical history, skin condition, previous treatments and expectations before recommending any injectable or procedural treatment. Tell the clinician about allergies, medications, active skin problems, pregnancy or breastfeeding, and any history of abnormal scarring or other relevant medical conditions.
How to Choose a Clinic for Acne-Scar Treatment
Choosing a clinic should involve more than comparing prices or promotional claims. A responsible consultation should explain what a treatment can and cannot achieve.
- Qualified practitioner: Confirm that your treatment will be assessed and performed by an appropriately qualified medical professional.
- Individual scar assessment: The clinician should distinguish between ice pick, boxcar, rolling and other scar types.
- Clear treatment rationale: Ask why Rejuran is being recommended and whether a scar-specific procedure may be more suitable.
- Transparent risks and costs: Request information about potential side effects, the expected number of appointments and the total estimated cost.
- Realistic expectations: Be cautious of promises of complete scar removal or guaranteed results.
- Follow-up plan: Understand how results and any complications will be reviewed.
Frequently Asked Questions
Does Rejuran really work for acne scars?
Rejuran may be considered to support overall skin quality and address certain texture concerns. However, evidence specifically for correcting established acne scars is limited compared with the broad claims sometimes made in marketing. Its suitability depends on the scar type, and deep or tethered scars may require other procedures.
Can Rejuran remove indented acne scars?
Rejuran should not be expected to remove indented acne scars completely. Ice pick, boxcar and rolling scars have different underlying structures, and treatments such as TCA CROSS, subcision, fractional resurfacing or other scar-directed procedures may be considered depending on the individual assessment.
How many Rejuran sessions are needed for acne scars?
There is no fixed number of sessions that applies to everyone. The recommended plan depends on your skin condition, treatment goals and the product and technique used. Your clinician should explain the expected benefits and when progress will be reviewed.
How long does Rejuran treatment take?
The appointment time varies according to the treatment area, consultation, skin preparation and clinic protocol. Ask your clinic how much time to allow for the complete appointment.
What side effects can occur after Rejuran?
Possible short-term reactions include injection-site bumps, redness, swelling, tenderness and bruising. Individual risks vary. Follow your clinician’s aftercare advice and seek medical attention if you experience severe or worsening pain, unusual skin colour changes, signs of infection, visual symptoms or another concerning reaction.
Can Rejuran be combined with laser or RF microneedling?
Some treatment plans may involve more than one procedure, but the choice and timing depend on the skin condition, treatment technique and recovery requirements. Do not combine procedures without a clinician’s assessment and a clear plan for managing risks and downtime.
Final Thoughts: Is Rejuran Worth Considering for Acne Scars?
Rejuran may be an option for people who want to address overall skin quality and certain texture concerns, but it is not a universal treatment for acne scars. The most appropriate approach depends on whether the main concern is general texture, shallow scarring, deep pits or tethered depressions.
For the best-informed decision, begin with a professional assessment of your scar type and discuss the expected benefits, limitations, risks, costs and alternatives. A personalised plan should focus on the specific cause of uneven texture rather than assuming that one treatment can correct every type of scar.
This article is for general educational purposes only and is not a substitute for an individual medical consultation. Treatment suitability and outcomes vary. Consult a qualified medical professional for advice specific to your skin and medical history.