Rejuran for Enlarged Pores: Does It Improve Texture?

Rejuran for Enlarged Pores: Can It Improve Skin Texture?

Enlarged pores can make the skin appear rough, uneven or less refined, particularly across the nose, cheeks and forehead. While skincare products may temporarily reduce shine or smooth the skin’s surface, they cannot always address the structural factors that make pores look more noticeable.

This has led to growing interest in Rejuran for enlarged pores. Rejuran is an injectable polynucleotide treatment designed to improve overall skin quality rather than add significant facial volume.

But can Rejuran genuinely make pores appear smaller?

Rejuran may help reduce the appearance of enlarged pores by improving skin hydration, elasticity, firmness and surface texture. However, results are usually gradual and depend heavily on why the pores are enlarged in the first place. Rejuran cannot permanently close pores, and it may not be the most suitable standalone treatment when excessive oil production, active acne or deep acne scarring is the main concern.

What Causes Enlarged Facial Pores?

Pores are natural openings connected to hair follicles and sebaceous glands. Everyone has them, and they cannot be removed completely.

Pores become more visible when their openings widen or when the surrounding skin loses support. Research identifies three major contributors to enlarged facial pores:

Acne, genetics, hormones, sun exposure, ageing and unsuitable skincare may also influence how noticeable pores appear. Because enlarged pores have several possible causes, treatment should be selected according to the underlying problem rather than using the same procedure for every patient.

For example, oily skin with blocked pores may respond better to acne management and sebum-controlling treatments. Pores caused mainly by declining elasticity and rough skin texture may benefit more from treatments that improve dermal support.

What Is Rejuran?

Rejuran is a brand of injectable skin treatment containing polynucleotides, commonly abbreviated as PN. Polynucleotides are highly purified, long-chain DNA fragments generally obtained from salmon-derived material.

Unlike a conventional dermal filler, Rejuran is not primarily intended to reshape the face or replace lost volume. It is commonly described as a regenerative or skin-quality treatment because it is placed within the skin to support gradual improvements in hydration, elasticity, firmness and texture.

Proposed mechanisms include supporting fibroblast activity, extracellular-matrix repair and the skin’s natural recovery processes. However, researchers have noted that the precise biological mechanisms and the strength of clinical evidence still require further investigation.

It is also important to understand that Rejuran is a specific brand, while polynucleotide injection is the broader treatment category. Research performed with one PN formulation does not automatically prove that every polynucleotide product will provide identical results.

Can Rejuran Reduce Enlarged Pores?

Rejuran may make enlarged pores appear less prominent, particularly when pore visibility is connected to:

By improving the quality and support of the skin surrounding each pore, Rejuran may create a smoother and more refined appearance. This does not mean that the pore disappears or physically closes. Instead, better-hydrated and firmer surrounding tissue can make the opening look less obvious.

A small randomized, double-blind study compared polynucleotide injections with non-crosslinked hyaluronic acid injections in 27 participants. Each participant received three treatments at two-week intervals. Although overall aesthetic improvement was similar between the two sides, the PN-treated side showed greater improvement in measured skin roughness and pore volume. No serious adverse events were reported.

These findings are encouraging, but they should be interpreted carefully. The study was small and focused on the area around the eyes rather than the oilier nose and central-cheek areas where enlarged pores are often most noticeable.

A separate survey involving 407 cosmetic physicians found that practitioners commonly used injectable polynucleotides for pores associated with reduced elasticity, excessive sebum and acne. However, a physician survey records clinical practices and opinions; it is not the same as a controlled clinical trial proving that the treatment works for every patient.

How Rejuran May Improve Skin Texture

Improved hydration

Dehydrated skin can appear rough, dull and uneven. When the skin is better hydrated, its surface may look smoother and light reflects more evenly.

Polynucleotide studies have reported improvements in hydration and elasticity, although outcomes and treatment protocols vary between studies.

Better elasticity around the pores

Loss of elasticity can reduce the structural support surrounding the follicle opening. This can make pores appear wider, particularly as the skin ages or experiences repeated sun exposure.

By improving general skin firmness and resilience, Rejuran may make these pores appear less stretched.

Smoother surface texture

If the skin surrounding a pore is rough or uneven, shadows can make the pore look deeper and more obvious. Improvements in surface smoothness may therefore produce a more refined appearance even when the actual pore structure has not changed dramatically.

Gradual skin-quality improvement

Rejuran is not usually associated with an instant pore-blurring effect. Temporary swelling may make the skin look plumper shortly after treatment, but meaningful changes in texture generally develop gradually as the skin responds over the following weeks.

What Rejuran Cannot Do

Managing expectations is essential before undergoing any injectable treatment.

Rejuran cannot:

Visible pores caused mainly by excessive oil may require a sebum-focused skincare or medical plan. Deep acne scars may respond better to procedures such as subcision, fractional laser treatment, chemical reconstruction or radiofrequency microneedling, depending on the scar type and skin tone.

Reviews of enlarged-pore treatments emphasise that successful treatment often requires multiple sessions and, in some cases, a combination of topical products and procedures. Younger patients may need greater focus on sebum control, while older patients may need both oil management and skin rejuvenation.

Who May Be a Good Candidate?

Rejuran may be worth discussing with a qualified medical practitioner when you have:

The treatment may be less effective as a standalone option if the pores are primarily caused by uncontrolled acne, very oily skin, prominent blackheads or deep scarring.

A detailed skin assessment is important because two people with similarly visible pores may need completely different treatment plans.

What Happens During a Rejuran Treatment?

Before treatment, the practitioner will normally assess your skin, medical history, allergies and previous cosmetic procedures. A topical numbing cream may be applied because multiple small injections are generally required across the treatment area.

The product is then delivered into the skin using a fine needle or an approved injection device. Small raised bumps may be visible at the injection points immediately after the procedure. These commonly settle as the product disperses.

Treatment schedules vary according to the product, treatment area and practitioner. Published PN studies have used different protocols, including courses of multiple sessions separated by several weeks. This variation is one reason patients should not assume that a single universal Rejuran schedule is suitable for everyone.

When Will You Notice Results?

Rejuran results are generally expected to develop progressively rather than immediately.

Some patients first notice improved hydration or a healthier-looking glow. Changes in texture, elasticity and pore visibility may take longer and often become clearer after completing a recommended treatment course.

The final outcome depends on factors including:

Maintenance treatment may be recommended because normal ageing, UV exposure and oil production continue after the initial course.

Is There Any Downtime?

Rejuran is minimally invasive, but it is not completely free from downtime.

Common temporary reactions can include:

Local injection-site reactions are among the most frequently reported issues with intradermal PN treatments. Published studies and reviews have generally described a favourable safety profile, but the available evidence base remains smaller than that for several established aesthetic treatments.

Any injection can potentially lead to complications such as infection, prolonged inflammation or an allergic reaction. Choosing a properly trained medical practitioner, using an authentic product and following sterile injection procedures are essential.

Who Should Avoid or Postpone Rejuran?

Rejuran may not be appropriate for everyone. Treatment will usually need to be avoided or postponed in people with:

Patients taking blood-thinning medicines or supplements should inform their practitioner. Prescribed medication should not be stopped without advice from the clinician who prescribed it.

Because products and regulations vary by country, patients should also confirm that the treatment and exact product are legally supplied and authorised in their location. In the United States, the FDA’s published dermal-filler information lists approved material categories and does not present polynucleotide products among those categories.

Rejuran vs Other Treatments for Enlarged Pores

Rejuran vs hyaluronic acid skin boosters

Hyaluronic acid skin boosters mainly focus on hydration and superficial plumping. Rejuran is generally selected when the treatment goal includes broader improvements in skin quality and texture.

A small split-face trial found similar overall aesthetic scores between PN and non-crosslinked hyaluronic acid, although roughness and pore-volume improvements were greater on the PN-treated side.

Rejuran vs microneedling

Microneedling creates controlled micro-injuries intended to stimulate remodelling. It may be more suitable when enlarged pores are accompanied by mild acne scars.

Rejuran does not create the same mechanical remodelling effect, although the two treatments may sometimes be incorporated into a broader skin plan at appropriately separated appointments.

Rejuran vs radiofrequency microneedling

Radiofrequency microneedling combines needles with thermal energy and may provide more intensive treatment for laxity, pores and acne scars. It normally involves more post-treatment redness and carries different risks, particularly when inappropriate energy settings are used.

Rejuran may suit patients seeking a less energy-intensive skin-quality treatment, but it may provide subtler results.

Rejuran vs laser treatment

Fractional and non-ablative lasers can address pores, pigmentation, sun damage and textural irregularities. The correct device and settings must be selected according to skin type, because some patients have a greater risk of post-inflammatory pigmentation.

Rejuran may be used independently or as part of a professionally planned combination approach, but combining treatments should never be based solely on social-media trends.

How to Improve and Maintain Your Results

An effective home routine should support the treatment rather than irritate the skin.

A practitioner may recommend:

Strong acids, retinoids and exfoliating products may need to be paused around the procedure. Follow the personalised instructions provided by the treating practitioner rather than restarting active products based on a general online timeline.

Is Rejuran Worth It for Enlarged Pores?

Rejuran may be worth considering when enlarged pores are accompanied by dehydration, uneven texture or declining elasticity. It is more likely to provide a gradual, natural-looking refinement than a dramatic overnight transformation.

Current research suggests that polynucleotide injections may improve skin texture, roughness, hydration and pore appearance. However, the scientific evidence remains emerging. A systematic review found promising results across several studies but noted that only nine low- to moderate-quality studies involving 219 patients met its criteria. Differences in formulations, treatment areas and injection techniques also make it difficult to predict a universal outcome.

The best results are likely to come from correctly identifying why the pores are enlarged and selecting Rejuran only when it matches that cause.

Frequently Asked Questions

Does Rejuran permanently shrink pores?

No. Rejuran cannot permanently close or remove pores. It may make them appear smaller by improving hydration, firmness and the texture of the surrounding skin.

How many Rejuran treatments are needed for enlarged pores?

Treatment plans vary. Many practitioners recommend a course rather than one appointment, but the number and spacing of sessions should be determined after assessing the skin, treatment area and product being used.

Is Rejuran good for oily skin?

It may improve overall texture, but it is not primarily a sebum-control treatment. When excessive oil is the main cause of enlarged pores, skincare, acne treatment or procedures that target sebum production may be more appropriate.

Can Rejuran treat acne scars?

Rejuran may improve mild textural irregularity and general skin quality. It is unlikely to correct deep or tethered acne scars on its own. Scar-specific treatments may be required.

Is Rejuran painful?

Multiple superficial injections can cause discomfort. Numbing cream may make the procedure more manageable, although sensitivity varies between patients and treatment areas.

Can Rejuran be combined with other treatments?

It may be incorporated into a plan involving skincare, laser treatment, microneedling or other procedures. The timing and suitability of combinations should be decided by a qualified medical practitioner.

Final Thoughts

Rejuran for enlarged pores may improve the appearance of pores by supporting smoother texture, better hydration and stronger-looking skin. It appears most relevant when pore visibility is linked to reduced elasticity and declining skin quality rather than oil production alone.

Results should be expected to be gradual and subtle. Rejuran does not erase pores, cure acne or replace intensive treatment for deep acne scars.

A consultation with an experienced medical practitioner can determine what is causing the enlarged pores, whether Rejuran is suitable and whether another treatment—or a carefully planned combination—would provide a better result.

This article is provided for general educational purposes and does not replace personalised medical advice, diagnosis or treatment.