Rejuran and Profhilo are injectable treatments used to improve aspects of skin quality, but they work differently and may be suitable for different concerns. If you are considering skin rejuvenation in Malaysia, understanding the differences can help you have a more informed discussion with your aesthetic doctor.
Rejuran is commonly associated with polynucleotide (PN) formulations and skin-quality improvement, while Profhilo is a hyaluronic acid-based injectable treatment designed to improve skin hydration and overall quality. Neither treatment is universally better for everyone. The more suitable option depends on your skin concerns, treatment goals, medical suitability and your doctor’s assessment.
In this guide, we compare Rejuran vs Profhilo, including how they work, their potential benefits, treatment experience, recovery, results, costs and how to decide which treatment to discuss with your doctor.
Rejuran vs Profhilo: What Is the Main Difference?
The main difference between Rejuran and Profhilo is their formulation and treatment approach. Rejuran uses polynucleotides, whereas Profhilo uses a formulation of hyaluronic acid. Both are injectable treatments, but they are not interchangeable and should not be selected based on a single benefit alone.
| Comparison | Rejuran | Profhilo |
|---|---|---|
| Main ingredient | Polynucleotides (PN), depending on the product formulation | Hyaluronic acid |
| General treatment focus | Skin quality and the appearance of texture and fine lines | Skin hydration, quality and the appearance of laxity |
| Potentially relevant concerns | Uneven-looking texture, fine lines and selected skin-quality concerns | Dehydrated-looking skin, reduced skin elasticity and early signs of laxity |
| Treatment approach | Multiple small injections into selected areas, depending on the protocol | Injection technique and treatment points depend on the protocol and area treated |
| Number of sessions | Depends on the product, treatment plan and individual response | Often planned as a course of treatments, depending on the protocol |
| Downtime | Temporary injection marks, bumps, redness or bruising may occur | Temporary injection-site bumps, swelling, redness or bruising may occur |
This table provides a general overview only. Product formulations, approved uses, injection methods and treatment protocols can differ. A consultation is necessary to determine whether either treatment is appropriate for you.
What Is Rejuran?
Rejuran is an injectable treatment associated with polynucleotides (PN). It is used in aesthetic practice to address selected skin-quality concerns. Depending on the formulation and treatment plan, the aim may be to improve the appearance of skin texture, fine lines and overall skin condition.
Rejuran is not the same as a conventional hyaluronic acid dermal filler. The intended treatment approach and expected outcome are different, so it is important to clarify which specific Rejuran product is being recommended and what it is expected to achieve.
Potential Benefits of Rejuran
- Skin texture: May help improve the appearance of uneven skin texture in suitable patients.
- Fine lines: May be considered for selected fine lines and visible signs of skin ageing.
- Overall skin quality: May form part of a treatment plan for patients seeking improvements in the appearance and condition of their skin.
- Targeted treatment: Different formulations may be intended for different areas or concerns. The correct product should be selected by a qualified practitioner.
Results vary from person to person. Rejuran should not be presented as a guaranteed treatment for acne scars, enlarged pores, pigmentation or every form of skin ageing. The suitability of treatment depends on the underlying concern and an individual assessment.
What Is Profhilo?
Profhilo is an injectable treatment based on hyaluronic acid. Hyaluronic acid is known for its ability to bind water, which is one reason it is used in aesthetic treatments focused on skin hydration and quality.
Profhilo is generally discussed as a skin-remodelling or skin-quality treatment rather than a conventional dermal filler intended to create specific areas of volume. Its treatment goals may include improving the appearance of hydration, elasticity and skin laxity, depending on the individual and treatment protocol.
Potential Benefits of Profhilo
- Skin hydration: May help improve the appearance of dehydrated skin.
- Skin elasticity: May be considered when the goal is to improve the appearance of skin firmness and elasticity.
- Early skin laxity: May suit selected patients who notice that their skin looks less firm than before.
- Overall skin quality: May be used as part of a broader skin-rejuvenation plan.
Profhilo is not a surgical facelift and should not be expected to correct significant sagging or replace treatments designed for other concerns. Your practitioner should explain the likely benefits and limitations for your particular skin condition.
Rejuran vs Profhilo for Different Skin Concerns
1. Skin Hydration
If your main concern is skin that looks dehydrated or lacks a fresh appearance, Profhilo may be one option to discuss because its formulation is based on hyaluronic acid.
Rejuran may also be considered as part of a skin-quality plan, but the two treatments have different formulations and should not be assumed to deliver identical effects. Your doctor can assess whether dehydration is the main concern or whether another skin condition is contributing to the appearance of your skin.
2. Fine Lines and Uneven Skin Texture
Both treatments may be discussed for patients concerned about visible signs of skin ageing, but the most suitable approach depends on the type and depth of the lines, the condition of the skin and the desired outcome.
Rejuran may be considered when the treatment goal focuses on skin quality and texture. Profhilo may be considered when hydration and overall skin quality are important goals. Neither treatment guarantees the removal of fine lines or produces the same outcome in every patient.
3. Skin Laxity and Loss of Firmness
Patients who notice reduced skin firmness may consider discussing Profhilo with their doctor. However, the extent of laxity matters. Injectable skin-quality treatments are not equivalent to surgical lifting, and they may have limited effects when sagging is more pronounced.
Rejuran may be considered for selected skin-quality concerns, but it should not automatically be treated as a substitute for a treatment specifically chosen to address significant skin laxity.
4. Under-Eye Concerns
The under-eye area is delicate, and concerns such as fine lines, dark circles, hollowing and puffiness can have different causes. No single injectable treatment is suitable for all of them.
Some Rejuran formulations are marketed for specific areas, including the eye area. However, the exact product, its suitability and the practitioner’s experience are important considerations. Profhilo should not automatically be assumed to be suitable for every under-eye concern either.
Before treatment, ask your doctor to identify the likely cause of the concern and explain the expected benefits, risks and alternatives for the specific area.
5. Acne Scars and Enlarged Pores
Acne scars and enlarged pores can result from different changes in the skin. Their appearance may be influenced by scar depth, oil production, skin texture and other factors.
Rejuran may be discussed as part of a skin-quality treatment plan for selected patients, but it should not be described as a guaranteed solution for acne scars or enlarged pores. Profhilo is not specifically a universal acne-scar treatment either.
If acne scarring is your main concern, a doctor may need to assess whether other treatments are more appropriate. Learn more about Rejuran for acne scars and discuss your options with a qualified practitioner.
Rejuran vs Profhilo: Which Gives Faster Results?
Neither treatment has a single result timeline that applies to everyone. The time needed to notice a change depends on the product, the treatment protocol, the initial condition of the skin and the individual’s response.
Some patients may notice changes in skin appearance earlier than others, while improvements may be gradual. The number of sessions and the interval between them should be determined by the treating practitioner rather than following a fixed schedule without assessment.
During your consultation, ask your doctor:
- When might I reasonably expect to notice changes?
- How many sessions are recommended for my concern?
- How will we assess whether the treatment is working?
- When should I return for a review?
- How long might the results last, and would maintenance be appropriate?
How Many Sessions Do You Need?
The number of sessions varies according to the treatment selected, the product used, the area being treated and the practitioner’s assessment. Some treatment plans involve an initial course followed by review or maintenance, but there is no universal schedule that is right for every patient.
Rather than choosing a treatment based on the number of sessions alone, ask for a personalised plan that explains the purpose of each session, the expected timeline and the total estimated cost.
Rejuran vs Profhilo: Pain and Downtime
Both Rejuran and Profhilo involve injections, so some discomfort is possible. The level of discomfort depends on factors such as the treatment area, injection technique and individual sensitivity.
Temporary reactions may include:
- Redness or swelling around injection sites
- Small raised bumps at injection points
- Tenderness or discomfort
- Bruising
These effects may settle over time, but recovery varies. Your practitioner should provide specific aftercare instructions and explain which symptoms are expected and which require medical attention.
Although uncommon, injectable treatments can cause more serious complications, including infection, allergic reactions or other product- and injection-related problems. Seek prompt medical assessment if you experience severe or worsening pain, unusual skin colour changes, spreading redness, fever, visual symptoms or other concerning symptoms.
For further information about recovery, read Rejuran downtime after treatment.
Rejuran vs Profhilo: Cost in Malaysia
The cost of Rejuran and Profhilo in Malaysia can vary by clinic, product formulation, treatment area, amount used, practitioner and number of sessions recommended. A quoted price for one product or protocol should not be assumed to apply to another.
Rather than relying on general prices from overseas websites, ask the clinic for a current quotation in Malaysian ringgit (RM) based on your treatment plan.
When comparing quotations, check:
- The exact product and formulation being used
- The amount or number of syringes included
- The area being treated
- The recommended number of sessions
- Whether follow-up appointments or maintenance treatments are included
- Who will perform the procedure and what aftercare is provided
The lowest initial price is not necessarily the best value. Make sure you understand what is included and whether the proposed treatment is appropriate for your concern before making a decision.
Can Rejuran and Profhilo Be Combined?
In some cases, a practitioner may consider different treatments as part of a broader skin-rejuvenation plan. However, combining Rejuran and Profhilo is not necessary for everyone and should not be assumed to produce better results.
Your doctor should assess whether both treatments have a clear role in addressing your concerns, whether they should be performed at different times, and whether the additional cost and risks are justified. Avoid combining injectable treatments without professional guidance.
Who May Be More Suitable for Rejuran?
Rejuran may be worth discussing with a qualified aesthetic doctor if your main goals involve selected skin-quality concerns, such as the appearance of uneven texture or fine lines, and the practitioner believes the specific formulation is appropriate.
It may not be the best choice for every skin concern. Your doctor should explain realistic outcomes, alternative treatments and any limitations based on your skin condition and medical history.
Who May Be More Suitable for Profhilo?
Profhilo may be worth discussing if your primary goals include improving the appearance of skin hydration, elasticity or early laxity and the practitioner considers you a suitable candidate.
It is not a replacement for every injectable, energy-based or surgical procedure. If your concern involves significant sagging, deep scars, pigmentation or substantial volume loss, your doctor may recommend a different approach.
How to Choose Between Rejuran and Profhilo
The right treatment should be selected according to your main concern rather than popularity alone. Before making a decision, consider the following:
- Identify your primary concern. Decide whether you are most concerned about hydration, texture, fine lines, laxity, under-eye changes or acne scarring.
- Ask about the exact product. Confirm which formulation will be used and what it is intended to address.
- Understand the expected outcome. Ask what improvement is realistic and what the treatment is unlikely to change.
- Compare the complete treatment plan. Consider the number of sessions, follow-up care, recovery and total estimated cost.
- Review the risks and alternatives. Make sure you understand potential side effects and other suitable options before consenting to treatment.
A consultation with a qualified medical practitioner is the best way to determine whether Rejuran, Profhilo or another treatment is more appropriate for your needs.
Frequently Asked Questions
Is Rejuran better than Profhilo?
Neither treatment is universally better. Rejuran uses polynucleotides, while Profhilo uses hyaluronic acid. The more appropriate option depends on your skin concerns, treatment goals, medical suitability and your doctor’s assessment.
Can Rejuran and Profhilo treat the same concerns?
There can be some overlap in the skin-quality concerns for which they are considered, but their formulations and intended treatment approaches differ. They should not be treated as interchangeable, and the expected outcome should be discussed with your practitioner.
Which is better for skin hydration?
Profhilo is a hyaluronic acid-based injectable and may be considered when improving the appearance of hydration is a primary goal. Your doctor should assess whether it is suitable and whether another treatment or skincare approach would be more appropriate.
Which is better for fine lines?
The answer depends on the type and cause of the fine lines and the condition of your skin. Rejuran and Profhilo may be considered in different skin-quality treatment plans, but neither guarantees that fine lines will disappear. A professional assessment can help identify suitable options.
Can Rejuran remove acne scars?
Rejuran may be considered for selected skin-quality concerns, but it should not be expected to remove all acne scars. Scar type and depth influence treatment choice, and other procedures may be more appropriate for some scars.
How long do Rejuran and Profhilo results last?
Results and their duration vary according to the product, treatment protocol and individual response. Ask your practitioner for a realistic estimate based on your treatment plan and whether maintenance may be appropriate.
How many sessions of Rejuran or Profhilo are needed?
The recommended number of sessions depends on the product, area treated and your individual goals. Your practitioner should explain the proposed schedule and review your response before recommending further treatment.
Is there downtime after Rejuran or Profhilo?
Temporary swelling, redness, bruising, tenderness or small bumps at injection sites may occur with either treatment. Recovery varies, so follow the aftercare instructions provided by your practitioner and seek medical advice if symptoms are severe or worsening.
How much do Rejuran and Profhilo cost in Malaysia?
Prices vary by clinic, product, treatment area and number of sessions. Request a current quotation in RM that specifies the exact product, amount included and complete treatment plan.
Find Out Which Skin Rejuvenation Treatment Is Right for You
Rejuran and Profhilo offer different approaches to injectable skin rejuvenation. The best option depends on your individual skin concerns, expectations, medical suitability and the treatment plan recommended by your doctor.
At Maple Clinic, you can discuss your concerns with a qualified practitioner and learn about the available treatment options, expected outcomes, risks and costs before deciding how to proceed.
Learn more about Rejuran treatment and discuss whether it is suitable for your skin.