What Is Rejuran and How Does It Improve Skin Quality?
As we age, changes in the skin are not limited to wrinkles. The skin may gradually become drier, thinner and less elastic, while pores and uneven texture can become more noticeable.
Skincare can support the surface of the skin, but some patients are looking for a treatment that focuses more directly on skin quality and regeneration.
This is where Rejuran comes in.
Rejuran is an injectable treatment based on polynucleotides (PN). Rather than primarily adding volume or changing facial contours, it is designed to support the skin’s natural repair and regenerative processes.
But what exactly is Rejuran, how does it work, and what changes can you realistically expect?
What Is Rejuran?
Rejuran is a polynucleotide-based injectable skin treatment. Polynucleotides are purified DNA fragments that are used in aesthetic medicine to support tissue repair and skin regeneration.
Unlike a conventional dermal filler, Rejuran is not primarily designed to restore facial volume or create a more defined contour.
Its focus is the quality and condition of the skin.
Depending on the formulation and treatment area, Rejuran may be used to address concerns such as:
- Fine lines
- Uneven skin texture
- Dull-looking skin
- Reduced elasticity
- Dehydrated-looking skin
- Enlarged-looking pores
- Thin or fragile-looking skin
- Mild acne scarring
- Early signs of skin ageing
Different formulations may be selected according to the patient’s concern and treatment area. You can learn more about Rejuran treatment in Malaysia and the available treatment approaches.
What Are Polynucleotides?
Polynucleotides are chains of nucleotides, which are the building blocks of DNA.
In aesthetic medicine, purified polynucleotides are used because of their potential role in supporting tissue repair and regeneration.
Rather than thinking of PN as simply a substance that “fills” the skin, it is more useful to understand them as a material intended to create a supportive environment for the skin’s natural repair processes.
Research into polynucleotide-based treatments has explored their effects on fibroblasts, collagen-related processes, tissue repair and the extracellular matrix.
The exact clinical response can vary according to the product, treatment protocol and individual patient.
How Does Rejuran Work?
Rejuran works differently from treatments that rely primarily on volume replacement or muscle relaxation.
Once the polynucleotide-based product is injected into the targeted area, it is intended to support processes involved in tissue repair and skin regeneration.
One important area of interest is fibroblast activity.
Fibroblasts are skin cells involved in producing collagen and other components that help maintain the structure and resilience of the skin.
As the skin undergoes its natural remodelling process, Rejuran may contribute to gradual improvements in:
- Collagen support
- Skin elasticity
- Hydration
- Skin texture
- Firmness
- Overall skin resilience
This is why Rejuran is generally considered a skin-quality treatment, rather than a treatment designed to create an immediate change in facial shape.
How Does Rejuran Improve Skin Quality?
1. Rejuran May Improve Skin Hydration
Dehydrated skin can look dull, rough and more lined.
Although Rejuran is not simply a moisturising injection, improvements in skin condition and hydration can contribute to a smoother and healthier-looking complexion.
Patients may notice that the skin feels softer or more supple as treatment progresses.
However, the degree of hydration improvement varies between individuals and should not be compared directly with a dedicated hydrating skin booster.
2. Rejuran May Support Skin Elasticity
Elasticity is one of the characteristics that changes as skin ages.
Reduced collagen production, environmental exposure and the natural ageing process can gradually make the skin feel less firm and resilient.
By supporting regenerative processes within the skin, Rejuran may help improve the appearance of skin that has become less elastic.
The goal is not to produce a dramatic lifting effect, but to gradually improve the quality of the skin.
3. Rejuran May Improve Uneven Texture
Uneven texture can be caused by several factors, including ageing, dehydration, acne scarring and changes in collagen.
Rejuran may help improve the overall smoothness and quality of the skin through gradual remodelling.
This can be particularly useful when the concern is mild textural irregularity rather than a deep structural scar.
4. Rejuran May Soften Fine Lines
Fine lines are often more visible when skin becomes thinner, drier and less elastic.
By improving overall skin quality, Rejuran may make some fine lines appear less noticeable.
This is different from a neuromodulator, which works by reducing muscle activity, or a dermal filler, which adds volume beneath the skin.
Rejuran focuses more broadly on the condition of the skin itself.
5. Rejuran May Improve Skin Firmness
Rejuran does not produce the same immediate lifting effect as a surgical facelift or some energy-based tightening procedures.
Instead, any improvement in firmness is generally associated with gradual changes in skin quality and collagen support.
It may therefore be more suitable for patients experiencing early or moderate changes in skin quality rather than significant structural sagging. Explore skin tightening treatments at Maple Clinic.
6. Rejuran May Support Damaged or Fragile Skin
Skin affected by ageing, acne or environmental stress may become less resilient.
The regenerative focus of polynucleotides makes Rejuran an option for patients who want to support the overall condition of their skin rather than target only one visible line or spot.
What Skin Concerns Can Rejuran Address?
Rejuran may be considered for several skin-quality concerns.
Fine Lines and Early Ageing
Rejuran may help improve fine lines associated with reduced elasticity and declining skin quality.
Enlarged-Looking Pores
Pore visibility can be influenced by oil production, skin elasticity and collagen structure. Improving overall skin quality may make pores appear less prominent, although Rejuran does not permanently “close” pores.
Uneven Skin Texture
Patients with mild roughness or uneven texture may benefit from a treatment plan focused on improving the quality of the surrounding skin.
Acne Scars
Certain Rejuran formulations may be used for selected acne scars, particularly when improving tissue quality and texture is part of the treatment objective. However, deep ice-pick scars or strongly tethered scars usually require more targeted acne-scar procedures.
Under-Eye Skin
The under-eye area has thinner and more delicate skin. A formulation and injection technique appropriate for the eye area may be considered for concerns such as fine lines and reduced skin quality.
Rejuran Is Not a Traditional Dermal Filler
One of the most common misconceptions is that Rejuran and dermal fillers are interchangeable. They are not.
Dermal fillers are commonly used to restore or add volume, improve facial proportions and enhance contours.
Rejuran is primarily intended to improve skin quality.
For example, a patient with significant cheek volume loss may need a volumising approach, while a patient whose cheeks have adequate volume but whose skin looks thin, dry and uneven may be more interested in a regenerative skin treatment.
The treatment should therefore be selected according to the underlying concern.
Rejuran vs Skin Boosters
Rejuran is often compared with skin boosters because both can be used to improve skin quality.
However, “skin booster” is a broad category rather than one specific treatment.
Different skin boosters may contain different ingredients, including hyaluronic acid or other compounds.
Many are primarily focused on hydration and improving skin appearance.
Rejuran is specifically based on polynucleotides and has a stronger focus on regenerative support and skin repair.
The two approaches can overlap, but they should not automatically be treated as identical.
How Many Rejuran Sessions Do You Need?
The number of sessions depends on your treatment goal.
For general skin rejuvenation, a common treatment plan may involve around 3-4 sessions spaced 3-4 weeks apart.
For acne scars, the treatment course may be longer, with around 3-6 sessions spaced 4-6 weeks apart depending on the severity of the scars.
The actual number of treatments should be personalised according to the skin condition and response.
When Will You See Results?
Rejuran is not designed to produce an instant transformation.
Some patients may notice early improvements in hydration or overall skin appearance after the first treatment.
More noticeable changes generally develop progressively over the following weeks and after a series of treatments.
This is because the treatment is intended to support biological processes such as tissue repair and skin remodelling.
How Long Do Rejuran Results Last?
Results vary depending on:
- Age
- Skin condition
- Number of treatments
- Treatment area
- Lifestyle
- Sun exposure
- Skincare routine
- Ongoing ageing
Because the skin continues to age, maintenance treatments may be considered after the initial treatment course.
Rejuran should therefore be viewed as part of a longer-term skin-quality strategy rather than a permanent solution.
Is Rejuran Suitable for Malaysian Skin?
Rejuran can be considered for many Asian skin types, including Malaysian patients.
However, the fact that a treatment can be used across different skin types does not mean that every patient should receive exactly the same treatment.
Your doctor should assess your:
- Skin type and condition
- Main concerns
- History of pigmentation
- Acne or inflammation
- Previous aesthetic treatments
- Treatment goals
The injection technique and treatment protocol should then be adjusted accordingly.
What Can You Expect After Rejuran?
Small bumps at the injection sites can appear immediately after treatment.
Mild redness, swelling or bruising may also occur depending on the individual and treatment area.
These effects are generally temporary.
As the skin recovers, the visible injection marks settle and the longer-term skin-quality changes can gradually develop.
Following the recommended aftercare and protecting your skin from excessive sun exposure are important parts of the treatment process.
Who May Consider Rejuran?
Rejuran may be worth considering if you are concerned about:
- Early signs of ageing
- Fine lines
- Dull skin
- Uneven texture
- Reduced elasticity
- Enlarged-looking pores
- Thin or fragile-looking skin
- Selected acne scars
It may be less suitable as a standalone treatment when the main concern is severe sagging, significant facial volume loss or very deep acne scarring.
In these situations, another treatment or combination approach may be more appropriate.
Conclusion
Rejuran is a polynucleotide-based skin treatment designed to support skin regeneration and improve overall skin quality.
Rather than simply adding volume, it focuses on supporting the skin’s natural repair processes, which may gradually improve hydration, elasticity, texture, fine lines and skin resilience.
The results are progressive, and the best treatment plan depends on your skin condition and goals.
If you are considering Rejuran and want to know whether it is suitable for your skin, a medical assessment can help determine the appropriate formulation, treatment area and number of sessions.